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Enzyme Cleaning ProductsIndependent ratings for what actually works
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Surfaces

Enzyme Cleaners by Surface and Material

Material decides the method more than the mess does. A cleaner that works beautifully on carpet can lift finish off a hardwood floor, and concrete is porous enough that surface treatment rarely reaches the problem.

Carpet is the common case and the one where under-application does most of its damage, because there are three layers below the fiber you can see.

Sealed and unsealed versions of the same material behave completely differently. Unsealed concrete absorbs urine deep into the slab, and no amount of surface product reaches it.

What Homeowners Actually Report About Cleaning Enzymes on Carpet, Wood and Concrete

We read 3,983+ first-hand accounts from homeowners and pulled more than 68,000 retailer ratings. The same points come up again and again.

Sources: Reddit and retailer reviews

What Works

  • Fixed the problem permanently, not just for a few daysRaised repeatedly across Reddit and retailer reviews
  • It worked when other things had notRaised repeatedly across Reddit and retailer reviews
  • People buy it again, often by the gallonRaised repeatedly across Reddit and retailer reviews

What Doesn't Work

  • Widely felt to be expensiveRaised repeatedly across Reddit and retailer reviews
  • The fragrance bothers peopleRaised repeatedly across Reddit and retailer reviews

The one thing worth knowing. Almost every complaint about an enzyme cleaner turns out to be the same thing: not enough of it. These products need to soak all the way through to where the mess actually went, and most bottles never say that. Use more than feels sensible and give it time to work.

What People Rate Highest Here

Ranked on how consistently buyers say it worked, weighted by how many of them there are. Price is on every product page; it is not what decides this list.

Bissell PET PRO OXY Urine Eliminator
Most trusted here Bissell PET PRO OXY Urine Eliminator Bissell $23.99 93/100
Zep High Traffic Carpet Cleaner
Zep High Traffic Carpet Cleaner Zep $9.48 91/100
Sunny & Honey Carpet Cleaner Shampoo Solution for Machines
Sunny & Honey Carpet Cleaner Shampoo Solution for Machines Sunny & Honey $23.99 87/100
Bissell Oxy Stain Destroyer Pet
Bissell Oxy Stain Destroyer Pet Bissell $5.99 90/100

Prices last checked 17 August 2026. Follow the retailer link for the price you will actually pay.

Everything We Track Here

14 products.

Click any column heading to sort, twice to reverse.

ProductPricePer OunceRatingReviewsScore
Bissell PET PRO OXY Urine EliminatorBissell$23.9950¢4.7 / 5.029,60093
Sunny & Honey Carpet Cleaner Shampoo Solution for MachinesSunny & Honey$23.9975¢4.4 / 5.015,60087
Simple GreenSimple Green$17.99·4.7 / 5.09,60064
Zep High Traffic Carpet CleanerZep$9.484.6 / 5.05,30091
Rocco & Roxie Carpet Cleaner Solution, Pet Stain & Odor RemoverRocco & Roxie$20.37·4.5 / 5.01,90086
Bissell Oxy Stain Destroyer PetBissell$5.99·4.8 / 5.01,70090
OxiClean Carpet & Area Rug Pet Stain & Odor RemoverOxiClean$4.98·4.5 / 5.01,20085
Simple Solution Bramton Solution Extreme Stain And Odor Remover SpraySimple Solution$14.99·4.5 / 5.01,200·
OxiClean Carpet Spot & Stain RemoverOxiClean$6.47·4.6 / 5.073685
Bissell Professional Pet Stain and Odor Removing FormulaBissell$7.99·4.7 / 5.064386
Nature's Miracle Hard Floor Cleaner, Dual-Action Dog & Cat Stain and OdorNature's Miracle$21.7190¢4.4 / 5.056685
Zep High-Traffic Carpet Spot Remover & CleanerZep$12.98·4.5 / 5.037383
Bissell Pet Stain and Stink RemoverBissell$12.74·4.8 / 5.023884
Biokleen Bac-Out Multi-Surface Floor CleanerBiokleen$13.09·4.8 / 5.01581

Nothing on this page has been tested by us yet. Ratings are aggregated from retailer listings. Where a size was read from a product title rather than confirmed by hand, the per-ounce figure is marked as unverified on the product page.