Which enzyme cleaner actually works, and what it should cost
We track 248 products from 47 brands. We compare prices across every retailer that stocks them, work out what each one costs per ounce, and read what people report after living with them for six months.
Most enzyme cleaners work. The reason yours did not is almost always that you used too little. Cat urine soaks through carpet into the backing and the pad underneath, and a surface mist never reaches it.
Start With Your Problem
- Pet stains and smellsCat urine, dog urine, litter boxes, accidents on every surface in the house.
- Drains and septicSlow drains, drain flies, garbage disposals, septic tanks, grease.
- Laundry and fabricBlood, sweat, protein stains, and which detergents contain enzymes at all.
- Surfaces and materialsCarpet, hardwood, concrete, mattresses, upholstery, artificial turf.
- How enzyme cleaners workProtease, amylase, lipase. Which enzyme digests what, and why dwell time matters.
- Commercial and tradeConcentrates, gallons, grease traps, and the maths on dilution.
Cheapest Per Ounce Right Now, Pet Formulas
Sorted by cost per fluid ounce inside a single comparison set, because a gallon of drain treatment and a spray bottle for the cat are not comparable and pretending otherwise produces nonsense.
Lowest per ounce Nature’s Miracle Cat Stain & Odor Remover, Enzymatic Cleaner, 1… Nature's Miracle · 4.5/5.0 · 7,500 reviews $24.97 67 20¢ an ounce, size unverified
Nature's Miracle Oxy Set-In Stain Destroyer, Cat Odor Control, 1… Nature's Miracle · 4.5/5.0 · 5,000 reviews $35.99 55 28¢ an ounce, size unverified
Nature's Miracle Urine Destroyer, Cat Urine Enzyme Cleaner, Pour… Nature's Miracle · 4.6/5.0 · 845 reviews $35.99 51 28¢ an ounce, size unverified
Nature's Miracle Hard Floor Cleaner, Stain & Odor Remover, 24 oz… Nature's Miracle · 4.5/5.0 · 1,000 reviews $8.99 58 37¢ an ounce, size unverified
Prices last checked 17 August 2026. Follow the retailer link for the price you will actually pay.
Brands We Track
-
Rocco & Roxie8 products · 4.5/5.0 across 263,052 ratings 56
-
Green Gobbler20 products · 4.3/5.0 across 223,627 ratings 51
-
Angry Orange4 products · 4.3/5.0 across 186,400 ratings 47
-
Nature's Miracle34 products · 4.5/5.0 across 151,821 ratings 54
-
Arm & Hammer5 products · 4.6/5.0 across 74,187 ratings 65
-
OxiClean6 products · 4.5/5.0 across 54,401 ratings 64
-
Simple Solution7 products · 4.4/5.0 across 49,895 ratings 54
- Active11 products · 4.5/5.0 across 40,273 ratings 60
- Thornell / Odorcide4 products · 4.5/5.0 across 40,100 ratings 52
- Rid-X6 products · 4.7/5.0 across 39,192 ratings 63
-
Bissell7 products · 4.7/5.0 across 37,549 ratings 63
-
Resolve5 products · 4.6/5.0 across 30,203 ratings 67