Skip to content
Enzyme Cleaning ProductsTested, priced, independent

Which enzyme cleaner actually works, and what it should cost

We track 248 products from 47 brands. We compare prices across every retailer that stocks them, work out what each one costs per ounce, and read what people report after living with them for six months.

Most enzyme cleaners work. The reason yours did not is almost always that you used too little. Cat urine soaks through carpet into the backing and the pad underneath, and a surface mist never reaches it.

Start With Your Problem

Cheapest Per Ounce Right Now, Pet Formulas

Sorted by cost per fluid ounce inside a single comparison set, because a gallon of drain treatment and a spray bottle for the cat are not comparable and pretending otherwise produces nonsense.

Nature’s Miracle Cat Stain & Odor Remover, Enzymatic Cleaner, 1 gal | Tough on Cat Urine, Feces, Vomit, Drool
Lowest per ounce Nature’s Miracle Cat Stain & Odor Remover, Enzymatic Cleaner, 1… Nature's Miracle · 4.5/5.0 · 7,500 reviews $24.97 67 20¢ an ounce, size unverified
Nature's Miracle Oxy Set-In Stain Destroyer, Cat Odor Control, 1 gal | Oxy Formula Penetrates, Separates & Lif
Nature's Miracle Oxy Set-In Stain Destroyer, Cat Odor Control, 1… Nature's Miracle · 4.5/5.0 · 5,000 reviews $35.99 55 28¢ an ounce, size unverified
Nature's Miracle Urine Destroyer, Cat Urine Enzyme Cleaner, Pour, 128 fl oz
Nature's Miracle Urine Destroyer, Cat Urine Enzyme Cleaner, Pour… Nature's Miracle · 4.6/5.0 · 845 reviews $35.99 51 28¢ an ounce, size unverified
Nature's Miracle Hard Floor Cleaner, Stain & Odor Remover, 24 oz | Bio-Enzymatic Formula Destroys Tough Pet St
Nature's Miracle Hard Floor Cleaner, Stain & Odor Remover, 24 oz… Nature's Miracle · 4.5/5.0 · 1,000 reviews $8.99 58 37¢ an ounce, size unverified

Prices last checked 17 August 2026. Follow the retailer link for the price you will actually pay.

Brands We Track

See all 47 brands