Do Simple Solution enzyme cleaners actually work?

Yes. Enzyme cleaners break the mess down rather than masking it, and Simple Solution products hold an average of 4.4 out of 5 across more than 49,000 buyer ratings. The most common reason any enzyme cleaner appears not to work is that too little was used for it to reach the mess.

How much does Simple Solution cost?

Simple Solution products we track run from $12.77 to $44.17, which works out to a median of about 47 cents an ounce.

How many Simple Solution products are there?

We track 8 Simple Solution products across 6 retailers.

Simple Solution

We track 8 Simple Solution products, priced between $12.77 and $44.17 across 6 retailers. Across everything they sell, the aggregate sits at 4.36 stars on more than 49,000 ratings.

/100 ECP Score

How we score

What People Like

Easy to findstocked by 6 retailers

What Doesn't Work

Nothing recurringNo repeated complaint across Reddit and retailer reviews

Use more than you think. The most common reason an enzyme cleaner seems to fail is that it never reached the mess. Soak the area through, not just the surface, and give it time.

Most bought, by review volume

Simple Solution Extreme Stain & Odor Remover, Enzyme Stain Cleaner

4.4 / 5.0 · 38,900 reviews

$14.99

See prices and details

Simple Solution Extreme Cat Stain Remover, Cat Spray Odor EliminatorCheapest per ounce within this brand 40¢an ounce

Everything Simple Solution sells that we track

Simple Solution Extreme Stain & Odor Remover, Enzyme Stain Cleaner

Simple Solution Extreme Stain & Odor Remover, Enzyme Stain Clean… Simple Solution $14.99 84/100

Simple Solution Hard Floor Dog Stain & Odor Remover, Enzyme Cleaner

Simple Solution Hard Floor Dog Stain & Odor Remover, Enzyme Clea… Simple Solution $14.99 82/100

Simple Solution Extreme Cat Stain Remover, Cat Spray Odor Eliminator

Simple Solution Extreme Cat Stain Remover, Cat Spray Odor Elimin… Simple Solution $12.77 85/100

Simple Solution Bramton Solution Extreme Stain And Odor Remover Spray

Simple Solution Bramton Solution Extreme Stain And Odor Remover… Simple Solution $14.99

Simple Solution Cat Extreme Stain and Odor Remover Simple Solution $12.77 81/100

Simple Solution Extreme Stain and Odour Remover for Cats Simple Solution $34.99 81/100

Simple Solution Extreme Urine Destroyer Simple Solution $13.95 80/100

Simple Solution Urine Destroyer Enzymatic Cleaner Pet Stain and Odor Remover

Simple Solution Urine Destroyer Enzymatic Cleaner Pet Stain and… Simple Solution $44.17 64/100

Prices last checked 17 August 2026. Follow the retailer link for the price you will actually pay.

Where It Is Sold

Amazon · Petco.com · PBS Animal Health · Big Frenchies · Tractor Supply Company · Chewy.com

Common Questions About Simple Solution

Do Simple Solution enzyme cleaners actually work?: Yes. Enzyme cleaners break the mess down rather than masking it, and Simple Solution products hold an average of 4.4 out of 5 across more than 49,000 buyer ratings. The most common reason any enzyme cleaner appears not to work is that too little was used for it to reach the mess.
How much does Simple Solution cost?: Simple Solution products we track run from $12.77 to $44.17, which works out to a median of about 47 cents an ounce.
How many Simple Solution products are there?: We track 8 Simple Solution products across 6 retailers.

What we have not done yet. Nobody here has physically tested a Simple Solution product. When that changes this page will carry the result, the substrate, the dwell time and the name of whoever ran it. Ratings above are aggregated from retailer listings and are not our judgement.